Fetal Brain Tissue Transplantation in Parkinsons Disease Patients Essa

Fetal outlook Tissue Transplantation in paralysis agitans Disease Patients shaking palsy illness is a neurological disorder characterized initially by muscular rigidity and slowing of voluntary movements (1). Ultimately, the characteristics are tremor, mask-like faces, decreased spontaneous blinking, flexion pusher and sometimes cognitive impairment. The neuropathology of Parkinsons disease generally involves red of mobile phone bodies in all melanin-containing brain regions and invariably a loss of substantia spade dopamine-containing neurons (DA). The principal target for dopaminergic neurons located in the substantia nigra is the striatum and the loss of dopaminergic tone in the striatum is thought to produce most of the symptoms of Parkinsons disease. Since Parkinsons disease is a dopamine deficiency, treatment with L-Dopa, the precursor of dopamine, was triple-crown in treating Parkinsons patients (1). However, these patients taking L-Dopa often develop font effects and in about 50% of the patients, the drug effectiveness is lost. As an alternative to drug therapy, the possibility of grafting dopamine-containing tissue into the brains was proposed. From the proposal, there confine been a vast amount of experiments to test transplantation effectiveness. Work in amphibians and fish were the first to demonstrate the possibilities for neuronal replacement after alter in the central nervous system (2). In these species, especially in the visual system, grafted neurons were substituted both structurally and functionally for damaged axonal connections, and corticipetal and efferent connections were established with a high degree of specificity between the grafted neurons and the host. indicate in adult sub-mammalian vertebrates has shown c... ...a, S., Brundin, P. and Gustavii, B., 1989, Human foetal dopamine neurons grafted into the striatum in two patients with severe Parkinsons disease. A detailed account of methodology and a 6-month follow-up. Archives of Neurology 46 615-631. 6. Freed, C.R., Breeze, R.E., Rosenberg, N.L. and Schneck, S.A., 1990, Transplantation of human fetal dopamine cells for Parkinsons disease. Results at 1 year. 47 505-512. 7. Jankovic, J., Grossman, R., Goodman, C. and Pirozzolo, F., 1989, Clinical, biochemical and neuropathologic findings sideline transplantation of adrenal medulla to the caudate gist for treatment of Parkinsons disease. Neurology 39 1227-1234. 8. Allen G.S., Burns, R.S., Tulipan, N.B. and Parker, R.A., 1989, Adrenal medullary transplantation to the caudate nucleus in Parkinsons disease. Initial clinical results in 18 patients. 46 487-491.